Our brief was to highlight the overstimulation of glutamate receptors due to increased release of glutamate into the synaptic cleft. This video is an excerpt from an academic presentation for current research on Huntington Disease (HD).
Huntington’s Disease is a fatal progressive neurodegenerative disorder. One proposed cellular mechanism underlying neuron degeneration is excitotoxic pathways mediated by glutamate receptors. Overstimulation of these receptors due to their enhanced responsiveness, or increased release or decreased uptake of glutamate, can result in neuronal stress or death via the excessive influx of water an ions, especially calcium. Read related article >